Buy 4-AcO-DMT Online – Premium Research Chemical
Buy 4-AcO-DMT Online – Premium Research Chemical
What Is 4-AcO-DMT?
4-AcO-DMT (4-acetoxy-N,N-dimethyltryptamine), also known as psilacetin or O-acetylpsilocin, is a semi-synthetic tryptamine and a research chemical of significant scientific interest. It is the O-acetylated prodrug of psilocin (4-hydroxy-N,N-dimethyltryptamine), meaning that it is metabolized to psilocin in the body, which is the same active compound found in psilocybin mushrooms .
Discovered in the 1960s by Albert Hofmann, the chemist who first synthesized LSD, 4-AcO-DMT remained relatively obscure until it began appearing as a research chemical in the early 21st century. It has since become a valuable tool for studying the pharmacology of psychedelic tryptamines .
Product Specifications
| Property | Details |
|---|---|
| Chemical Name | 4-Acetoxy-N,N-dimethyltryptamine / O-Acetylpsilocin / Psilacetin |
| IUPAC Name | 3-[2-(dimethylamino)ethyl]-1H-indol-4-yl acetate |
| CAS Number | 92292-84-7 |
| Molecular Formula | C₁₄H₁₈N₂O₂ |
| Molecular Weight | 246.31 g/mol |
| Chemical Class | Tryptamine |
| Form | Crystalline powder (typically fumarate salt) |
| Purity | Research grade (≥98%) |
| Storage | Store at -20°C, protected from light and moisture |
Pharmacology and Mechanism of Action
Psilocin Prodrug
In vivo, 4-AcO-DMT undergoes deacetylation, primarily through hydrolysis, to yield psilocin. In human liver microsomes, 15 metabolites have been identified, with psilocin being the most abundant . This metabolic profile distinguishes 4-AcO-DMT from psilocybin, which undergoes dephosphorylation as its primary activation step, potentially influencing the rate and extent of psilocin generation .
Receptor Binding Profile
4-AcO-DMT acts as a non-selective serotonin receptor agonist with strong activity at the 5-HT2A receptor . The receptor binding profile includes:
| Receptor | Affinity (Ki) |
|---|---|
| 5-HT2A | Active (full agonist) |
| 5-HT1A | Active |
| 5-HT2C | Active |
| 5-HT6 | Active |
| 5-HT7a | Active |
4-AcO-DMT binds to a broader range of serotonin receptors compared to psilocybin, which does not compete for binding at 5-HT2A or 5-HT5A receptors in primary screens . This broader receptor interaction may contribute to the distinct subjective effects reported by researchers.
Effects and Research Applications
Reported Psychoactive Effects
Researchers have documented a range of effects associated with 4-AcO-DMT, which are generally described as very similar to psilocybin:
Sensory Effects:
- Visual distortions and hallucinations (enhanced colors, geometric patterns, fractal images)
- Heightened sensory perception
- Changes in hearing and emotional responses to music
Emotional Effects:
Cognitive Effects:
- Nonlinear thinking and profound philosophical insights
- Altered sense of time (may speed up, slow down, or become irrelevant)
- Enhanced creativity
Comparative Advantages:
- Users often describe 4-AcO-DMT as having a smoother onset than psilocybin
- Reduced nausea compared to consuming natural mushrooms
- A “warmer” and “more euphoric” experience compared to psilocybin-containing mushrooms
Therapeutic Potential
Early research suggests that 4-AcO-DMT may hold therapeutic potential, particularly in treating mental health and substance use disorders . University of Michigan research has identified a psilacetin derivative shown to have anxiolytic properties, enhance learning and memory, and decrease alcohol consumption in addicted mice .
Dosage Information
According to research sources, common dosage ranges for 4-AcO-DMT are:
| Dose Level | Amount |
|---|---|
| Microdose | 2.5 mg (fumarate) – comparable to 0.2-0.4g dried psilocybin mushrooms |
| Mild | 5-10 mg |
| Standard | 10-25 mg |
| Strong | 25-30 mg |
Important Note: When using the fumarate salt form, 1.24 mg of fumarate equates to roughly 1 mg of freebase 4-AcO-DMT .
H2: Why Choose Colorado Shroom Store?
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Premium Quality Products
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Delivery Information – USA & Canada Shipping
USA Delivery
- Fast shipping to all 50 states
- Tracking number provided for all orders
- Discreet packaging ensuring your privacy
- Overnight delivery options available for urgent orders
Canada Delivery
- Secure delivery to select Canadian provinces
- Compliance with Canadian import regulations
- Camouflage packaging for discretion
- Real-time tracking information
Frequently Asked Questions (FAQs)
Q: What is 4-AcO-DMT?
A: 4-AcO-DMT (4-acetoxy-N,N-dimethyltryptamine) is a synthetic tryptamine and a research chemical. It is the O-acetylated prodrug of psilocin (4-OH-DMT), the active compound found in psilocybin mushrooms .
Q: What is the CAS number for 4-AcO-DMT?
A: The CAS number is 92292-84-7.
Q: What is the mechanism of action of 4-AcO-DMT?
A: 4-AcO-DMT acts as a prodrug for psilocin, which is a non-selective serotonin receptor agonist with strong activity at the 5-HT2A receptor .
Q: What are the research applications of 4-AcO-DMT?
A: Research applications include studying serotonin receptor pharmacology, structure-activity relationships (SAR) of tryptamines, metabolic profiling, and the development of analytical methods for forensic and clinical toxicology .
Q: Is 4-AcO-DMT a prodrug for psilocin?
A: Yes. The O-acetyl group is cleaved in the body, yielding psilocin (4-OH-DMT), which is responsible for the pharmacological effects observed in vivo .
Q: Is shipping discreet?
A: Yes, we use discreet packaging for all orders to ensure your privacy.
Q: What payment methods do you accept?
A: We offer multiple secure checkout options.
Q: How should 4-AcO-DMT be stored?
A: Store in a cool, dark, dry place at -20°C, protected from light and moisture
Legal Disclaimer: This product is intended for research and analytical purposes only. 4-AcO-DMT is a Schedule I substance in the United States and is regulated in many countries. This product is offered exclusively for legitimate research. Customers must possess all required licenses, permits, and authorizations under applicable controlled substances legislation. Must be 21+ to purchase. Ensure compliance with all applicable laws and regulations in your jurisdiction.